Characterization of the Nrf2 Response in Patients With ADPKD

Mayo Clinic

Overview

The purpose of this study is to characterize oxidative stress and the Nrf2 antioxidant response in early stages of ADPKD, while identifying candidate biomarkers. The study is observational and participants will not be asked to take an investigational drug or therapy.

During the study period, patients will be asked to provide blood and urine samples to determine biomarkers of oxidative status and antioxidant response to study redox balance at early stages of the disease. In addition, an abdominal MRI will be performed to determine patient’s total kidney volume (TKV).

 

You may be eligible for this study if you:

  • 18-30 years of age
  • Have been diagnosed with ADPKD
  • Have a lab value eGFR greater than 60 mL/min/1.73 m2

 

OR if you’re a healthy volunteer:

  • 18-30 years of age
  • Have a kidney function lab value eGFR greater than 60 mL/min/1.73 m2

 

Exclusion criteria:

  • Unable to undergo an MRI
  • Kidney or any other solid organ transplant recipient or a planned transplant during the study
  • Women who are pregnant or breastfeeding
  • Other eligibility criteria may apply

 

To find out more, contact the Mayo Clinic:

Dr. Maria Irazabal (Principal Investigator) @ irazabalmira.maria@mayo.edu or 507.884.5628

Kathleen Leistikow (Study Coordinator) @ leistikow.kathleen@mayo.edu or 507.266.1316