ADPKD Somatic Mutation Biorepository
Overview
This study is examining the genetic changes associated with the development of ADPKD using native kidneys removed from patients undergoing native nephrectomy at the time of living donor kidney transplantation. No therapeutic intervention is included in the protocol. ADPKD is caused by germline (primary) mutations in one of two PKD genes; however, there are very few published reports of the somatic (secondary) PKD gene mutations in kidneys of patients with ADPKD and how they correlate with the clinical phenotype.
This is not a treatment study. Instead, we ask for donations of PKD kidneys after nephrectomy for research use.
Participation Criteria:
- 18 years of age or older
- A diagnosis of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
- Undergoing a nephrectomy of PKD kidneys in the near future
Location
- Rogosin Institute
- NY, 10021, USA
- Contact: Stephanie Donahue, NP 212-746-1591
- Principle Investigator: Hanna Rennert, PhD 212-746-6412 har2006@med.cornell.edu