MDR-101-MLK (MERCURY) Study: Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants
Overview
Currently, patients receiving a transplanted kidney are required to take life-long immunosuppressive medications to prevent rejection of the transplanted kidney. These medications carry substantial side effects. In addition, these medicines often do not completely control damage to the kidney from the recipients’ immune system, ultimately causing the kidney to fail.
This study is looking at a novel cell-based therapy to reprogram the recipients’ immune system to accept a transplanted kidney without the need for long term use of immunosuppression drugs.
The purpose of the current Phase 3 study is to demonstrate the efficacy and safety of MDR-101 for the induction of transplant immune tolerance in a prospective, randomized, multicenter clinical trial. MDR-101 is intended to induce mixed lymphohematopoietic chimerism and donor specific immune tolerance in order to preserve transplant kidney function, avert transplant kidney rejection, and eliminate the cumulative and serious side effects associated with immunosuppressive drugs.
Patients will receive either standard anti-rejection medications or a single dose of MDR-101 via IV infustion post-kidney transplant.
The investigational drug and study-related procedures will be provided at no cost. There may also be compensation available for study-related travel and expenses.
You may be eligible for this study if you:
- Are between 18 to 70 years of age;
- Have a living, related kidney donation scheduled or upcoming
- Are HLA and ABO matched with donor
Exclusion criteria:
- Currently taking immunosuppressive therapy
- Donor with a history of type 1 or type 2 diabetes melliltus
- Other eligibility criteria may apply
Find out if you might be eligible by contacting:
Lenuta Micsa, MD @ 646.239.9748 or [email protected]
Mercury Medeor @ 646.239.9748 or [email protected]
Locations:
UNITED STATES —
Arizona
- Mayo Clinic Arizona
- Phoenix, AZ
- Contact: Caroline Jadlowiec 480-342-6429 [email protected]
California
- University of California San Diego Moores Cancer Center
- La Jolla, California, United States, 92037
- Contact: Mita Shah, M.D. 858-657-8043 [email protected]
- Loma Linda University Medical Center
- Loma Linda, California, United States, 92354
- Contact: Michael De Vera, MD 909-558-3650 [email protected]
- Contact: Diane Scavone 909-558-3670 [email protected]
- USC
- Los Angeles, California, United States, 90033
- Contact: Yasir Qazi, M.D. 323-442-5100 [email protected]
- Contact: Lily Jara 3234426038 [email protected]
- Stanford University Medical Center
- Stanford, California, United States, 94305
- Contact: Stephan Busque, MD 650-498-6189 [email protected]
- Contact: Asha Shori 650-736-0245 [email protected]
Colorado
- University of Colorado
- Aurora, Colorado, United States, 80045
- Contact: Erik Stites, MD [email protected]
- Contact: Janis Cicerchi 303-724-0183 [email protected]
Connecticut
- Yale University
- New Haven, Connecticut, United States, 06519
- Contact: Ethan Marin, MD 203-785-6221 [email protected]
- Contact: Ricarda Tomlin 203-785-2073 [email protected]
District of Columbia
- Georgetown University Medical Center
- Washington, District of Columbia, United States, 20007
- Contact: Takeda Harris 202-444-6395 [email protected]
Florida
- Mayo Clinic Hospital
- Jacksonville, Florida, United States, 32224
- Contact: Martin Mai 904-953-2000 [email protected]
Illinois
- Loyola University Medical Center
- Maywood, Illinois, United States, 60153-3328
- Contact: Sanjeev Akkina 708-216-6389 [email protected]
- Contact: Mary Rose Evans [email protected]
Massachusetts
- Beth Israel Deaconess Medical Center
- Boston, Massachusetts, United States, 02215
- Contact: Susan McDermott, RN 617-632-9841 [email protected]
- Contact: Catherine Helzer 617-632-9919 [email protected]
Minnesota
- Mayo Clinic
- Rochester, Minnesota, United States, 55905
- Contact: Mark Stegall, MD 507-266-2812 [email protected]
- Contact: Nong Braaten 507-538-9617 [email protected]
New Jersey
- RWJ Barnabas Health
- Orange, New Jersey, United States, 07052
- Contact: Anup Patel, MD 973-322-2146 [email protected]
- Contact: Nasreen Ali 973-322-2165 [email protected]
New York
- Upstate University Hospital
- Syracuse, New York, United States, 13210
- Contact: Mark Laftavi, M.D. 716-898-3394 [email protected]
- Contact: Iulia Movileanu 3154644766 [email protected]
Ohio
- University Hospitals Cleveland Medical Center
- Cleveland, Ohio, United States, 44106
- Contact: Kenneth Chavin, MD 216-844-5396 [email protected]
- Contact: Tricia Young (216) 844-5396 [email protected]
Pennsylvania
- Thomas Jefferson University
- Philadelphia, Pennsylvania, United States, 19107
- Contact: Ashesh Shah, MD 317-496-7944 [email protected]
- Contact: Dee Rinaldi 215-503-1765 [email protected]
Texas
- Baylor University Medical Center
- Dallas, Texas, United States, 75246
- Contact: Bernard Fischbach, M.D. 817-922-7667 [email protected]
- Contact: Sharon Primeaux [email protected]
- The Methodist Hospital
- Houston, Texas, United States, 77030
- Contact: Ahmed Gaber, MD 713-441-6174 [email protected]
- Contact: Darrel Cleere 713-441-6232 [email protected]
Utah
- Intermountain Transplant Center
- Murray, Utah, United States, 84107
- Contact: Diane Alonso, MD 801-507-9600 [email protected]
- Contact: Jake Krong 801-507-9333 J[email protected]
Virginia
- INOVA Fairfax Hospital
- Fairfax, Virginia, United States, 22031
- Contact: James Piper, MD 703-531-2246 [email protected]
- Contact: Mallory Frazier 202-841-0498 [email protected]
Wisconsin
- University of Wisconsin
- Madison, Wisconsin, United States, 53792
- Contact: Dixon B Kaufman, MD 312-908-2000 [email protected]
- Contact: Kaelin Grant 6082621551 [email protected]
CANADA —
Quebec
- CIUSSS de l’Est- de-l’Île-de-Montréal Installation Hopital Maisonneuve-Rosemont
- Montréal, Quebec, Canada, H1T 2M4
- Contact: Suzon Collette 51425223403489 [email protected]
- Contact: Lucie Boutin 5142523400 [email protected]