MDR-101-MLK (MERCURY) Study: Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants

Multiple Locations

Overview

Currently, patients receiving a transplanted kidney are required to take life-long immunosuppressive medications to prevent rejection of the transplanted kidney. These medications carry substantial side effects. In addition, these medicines often do not completely control damage to the kidney from the recipients’ immune system, ultimately causing the kidney to fail.

This study is looking at a novel cell-based therapy to reprogram the recipients’ immune system to accept a transplanted kidney without the need for long term use of immunosuppression drugs.

The purpose of the current Phase 3 study is to demonstrate the efficacy and safety of MDR-101 for the induction of transplant immune tolerance in a prospective, randomized, multicenter clinical trial. MDR-101 is intended to induce mixed lymphohematopoietic chimerism and donor specific immune tolerance in order to preserve transplant kidney function, avert transplant kidney rejection, and eliminate the cumulative and serious side effects associated with immunosuppressive drugs.

Patients will receive either standard anti-rejection medications or a single dose of MDR-101 via IV infustion post-kidney transplant.

The investigational drug and study-related procedures will be provided at no cost. There may also be compensation available for study-related travel and expenses.

 

You may be eligible for this study if you:

  • Are between 18 to 70 years of age;
  • Have a living, related kidney donation scheduled or upcoming
  • Are HLA and ABO matched with donor

 

Exclusion criteria:

  • Currently taking immunosuppressive therapy
  • Donor with a history of type 1 or type 2 diabetes melliltus
  • Other eligibility criteria may apply

 

Find out if you might be eligible by contacting:

Lenuta Micsa, MD @ 646.239.9748 or lmicsa@medeortx.com

Mercury Medeor @ 646.239.9748 or mercury@medeortx.com

 

Locations:

UNITED STATES —

Arizona
Mayo Clinic Arizona
Phoenix, AZ

Contact: Caroline Jadlowiec    480-342-6429    jadlowiec.caroline@mayo.edu

 

California

University of California San Diego Moores Cancer Center

La Jolla, California, United States, 92037

Contact: Mita Shah, M.D.    858-657-8043    mshah@ucsd.edu  

 

Loma Linda University Medical Center

Loma Linda, California, United States, 92354

Contact: Michael De Vera, MD    909-558-3650    mdevera@llu.edu  

Contact: Diane Scavone    909-558-3670    dscavone@llu.edu

 

USC

Los Angeles, California, United States, 90033

Contact: Yasir Qazi, M.D.    323-442-5100    qaziy@usc.edu  

Contact: Lily Jara    3234426038    liliacna.jara@med.usc.edu  

 

Stanford University Medical Center

Stanford, California, United States, 94305

Contact: Stephan Busque, MD    650-498-6189    Stephan.busque@stanford.edu

Contact: Asha Shori    650-736-0245    ashas@stanford.edu

 

Colorado
University of Colorado

Aurora, Colorado, United States, 80045

Contact: Erik Stites, MD       ERIK.STITES@CUANSCHUTZ.EDU

Contact: Janis Cicerchi    303-724-0183    janis.cicerchi@ucdenver.edu 

 

Connecticut
Yale University

New Haven, Connecticut, United States, 06519

Contact: Ethan Marin, MD    203-785-6221    ethan.marin@yale.edu 

Contact: Ricarda Tomlin    203-785-2073    ricarda.tomlin@yale.edu  

 

District of Columbia

Georgetown University Medical Center

Washington, District of Columbia, United States, 20007

Contact: Takeda Harris    202-444-6395    takeda.m.harris@gunet.georgetown.edu  

 

Florida

Mayo Clinic Hospital     

Jacksonville, Florida, United States, 32224

Contact: Martin Mai    904-953-2000    mai.martin@mayo.edu 

 

Illinois

Loyola University Medical Center

Maywood, Illinois, United States, 60153-3328

Contact: Sanjeev Akkina    708-216-6389    sanjeev.akkina@lumc.edu

Contact: Mary Rose Evans       mevans11@luc.edu

 

Massachusetts

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States, 02215

Contact: Susan McDermott, RN    617-632-9841    smcderm2@bidmc.harvard.edu 

Contact: Catherine Helzer    617-632-9919    chelzer@bidmc.harvard.edu

 

Minnesota
Mayo Clinic

Rochester, Minnesota, United States, 55905

Contact: Mark Stegall, MD    507-266-2812    stegall.mark@mayo.edu 

Contact: Nong Braaten    507-538-9617    braaten.nong@mayo.edu 

 

New Jersey

RWJ Barnabas Health

Orange, New Jersey, United States, 07052

Contact: Anup Patel, MD    973-322-2146    anup.patel@rwjbh.org 

Contact: Nasreen Ali    973-322-2165    nasreen.ali@rwjbh.org 

 

New York

Upstate University Hospital

Syracuse, New York, United States, 13210

Contact: Mark Laftavi, M.D.    716-898-3394    mlaftavi@buffalo.edu

Contact: Iulia Movileanu    3154644766    movileai@upstate.edu 

 

Ohio

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States, 44106

Contact: Kenneth Chavin, MD    216-844-5396    kenneth.chavin@uhhospitals.org

Contact: Tricia Young    (216) 844-5396    tricia.young@uhhospitals.org 

 

Pennsylvania

Thomas Jefferson University

Philadelphia, Pennsylvania, United States, 19107

Contact: Ashesh Shah, MD    317-496-7944    ashesh.shah@jefferson.edu  

Contact: Dee Rinaldi    215-503-1765    dee.rinaldi@jefferson.edu

 

Texas

Baylor University Medical Center

Dallas, Texas, United States, 75246

Contact: Bernard Fischbach, M.D.    817-922-7667    bernard.fischbach@baylorhealth.edu 

Contact: Sharon Primeaux       sharon.primeaux@bswhealth.org  

 

The Methodist Hospital

Houston, Texas, United States, 77030

Contact: Ahmed Gaber, MD    713-441-6174    aogaber@houstonmethodist.org

Contact: Darrel Cleere    713-441-6232    dwcleere@houstonmethodist.org

 

Utah

Intermountain Transplant Center

Murray, Utah, United States, 84107

Contact: Diane Alonso, MD    801-507-9600    diane.alonso@imail.org 

Contact: Jake Krong    801-507-9333    Jake.Krong@imail.org

 

Virginia

INOVA Fairfax Hospital

Fairfax, Virginia, United States, 22031

Contact: James Piper, MD    703-531-2246    jamesb.piper@inova.org

Contact: Mallory Frazier    202-841-0498    mallory.frazier@inova.org  

 

Wisconsin
University of Wisconsin

Madison, Wisconsin, United States, 53792

Contact: Dixon B Kaufman, MD    312-908-2000    kaufman@surgery.wisc.edu

Contact: Kaelin Grant    6082621551    grantk@surgery.wisc.edu

 

 

CANADA —

Quebec

CIUSSS de l’Est- de-l’Île-de-Montréal Installation Hopital Maisonneuve-Rosemont

Montréal, Quebec, Canada, H1T 2M4

Contact: Suzon Collette    51425223403489    suzoncollette@gmail.com

Contact: Lucie Boutin    5142523400    lboutin.hmr@ssss.gouv.qc.ca