MDR-101-MLK (MERCURY) Study: Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants
Overview
Currently, patients receiving a transplanted kidney are required to take life-long immunosuppressive medications to prevent rejection of the transplanted kidney. These medications carry substantial side effects. In addition, these medicines often do not completely control damage to the kidney from the recipients’ immune system, ultimately causing the kidney to fail.
This study is looking at a novel cell-based therapy to reprogram the recipients’ immune system to accept a transplanted kidney without the need for long term use of immunosuppression drugs.
The purpose of the current Phase 3 study is to demonstrate the efficacy and safety of MDR-101 for the induction of transplant immune tolerance in a prospective, randomized, multicenter clinical trial. MDR-101 is intended to induce mixed lymphohematopoietic chimerism and donor specific immune tolerance in order to preserve transplant kidney function, avert transplant kidney rejection, and eliminate the cumulative and serious side effects associated with immunosuppressive drugs.
Patients will receive either standard anti-rejection medications or a single dose of MDR-101 via IV infustion post-kidney transplant.
The investigational drug and study-related procedures will be provided at no cost. There may also be compensation available for study-related travel and expenses.
You may be eligible for this study if you:
- Are between 18 to 70 years of age;
- Have a living, related kidney donation scheduled or upcoming
- Are HLA and ABO matched with donor
Exclusion criteria:
- Currently taking immunosuppressive therapy
- Donor with a history of type 1 or type 2 diabetes melliltus
- Other eligibility criteria may apply
Find out if you might be eligible by contacting:
Lenuta Micsa, MD @ 646.239.9748 or lmicsa@medeortx.com
Mercury Medeor @ 646.239.9748 or mercury@medeortx.com
Locations:
UNITED STATES —
Arizona
Mayo Clinic Arizona
Phoenix, AZ
Contact: Caroline Jadlowiec 480-342-6429 jadlowiec.caroline@mayo.edu
California
University of California San Diego Moores Cancer Center
La Jolla, California, United States, 92037
Contact: Mita Shah, M.D. 858-657-8043 mshah@ucsd.edu
Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Contact: Michael De Vera, MD 909-558-3650 mdevera@llu.edu
Contact: Diane Scavone 909-558-3670 dscavone@llu.edu
USC
Los Angeles, California, United States, 90033
Contact: Yasir Qazi, M.D. 323-442-5100 qaziy@usc.edu
Contact: Lily Jara 3234426038 liliacna.jara@med.usc.edu
Stanford University Medical Center
Stanford, California, United States, 94305
Contact: Stephan Busque, MD 650-498-6189 Stephan.busque@stanford.edu
Contact: Asha Shori 650-736-0245 ashas@stanford.edu
Colorado
University of Colorado
Aurora, Colorado, United States, 80045
Contact: Erik Stites, MD ERIK.STITES@CUANSCHUTZ.EDU
Contact: Janis Cicerchi 303-724-0183 janis.cicerchi@ucdenver.edu
Connecticut
Yale University
New Haven, Connecticut, United States, 06519
Contact: Ethan Marin, MD 203-785-6221 ethan.marin@yale.edu
Contact: Ricarda Tomlin 203-785-2073 ricarda.tomlin@yale.edu
District of Columbia
Georgetown University Medical Center
Washington, District of Columbia, United States, 20007
Contact: Takeda Harris 202-444-6395 takeda.m.harris@gunet.georgetown.edu
Florida
Jacksonville, Florida, United States, 32224
Contact: Martin Mai 904-953-2000 mai.martin@mayo.edu
Illinois
Loyola University Medical Center
Maywood, Illinois, United States, 60153-3328
Contact: Sanjeev Akkina 708-216-6389 sanjeev.akkina@lumc.edu
Contact: Mary Rose Evans mevans11@luc.edu
Massachusetts
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Contact: Susan McDermott, RN 617-632-9841 smcderm2@bidmc.harvard.edu
Contact: Catherine Helzer 617-632-9919 chelzer@bidmc.harvard.edu
Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Contact: Mark Stegall, MD 507-266-2812 stegall.mark@mayo.edu
Contact: Nong Braaten 507-538-9617 braaten.nong@mayo.edu
New Jersey
RWJ Barnabas Health
Orange, New Jersey, United States, 07052
Contact: Anup Patel, MD 973-322-2146 anup.patel@rwjbh.org
Contact: Nasreen Ali 973-322-2165 nasreen.ali@rwjbh.org
New York
Upstate University Hospital
Syracuse, New York, United States, 13210
Contact: Mark Laftavi, M.D. 716-898-3394 mlaftavi@buffalo.edu
Contact: Iulia Movileanu 3154644766 movileai@upstate.edu
Ohio
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Contact: Kenneth Chavin, MD 216-844-5396 kenneth.chavin@uhhospitals.org
Contact: Tricia Young (216) 844-5396 tricia.young@uhhospitals.org
Pennsylvania
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Contact: Ashesh Shah, MD 317-496-7944 ashesh.shah@jefferson.edu
Contact: Dee Rinaldi 215-503-1765 dee.rinaldi@jefferson.edu
Texas
Baylor University Medical Center
Dallas, Texas, United States, 75246
Contact: Bernard Fischbach, M.D. 817-922-7667 bernard.fischbach@baylorhealth.edu
Contact: Sharon Primeaux sharon.primeaux@bswhealth.org
The Methodist Hospital
Houston, Texas, United States, 77030
Contact: Ahmed Gaber, MD 713-441-6174 aogaber@houstonmethodist.org
Contact: Darrel Cleere 713-441-6232 dwcleere@houstonmethodist.org
Utah
Intermountain Transplant Center
Murray, Utah, United States, 84107
Contact: Diane Alonso, MD 801-507-9600 diane.alonso@imail.org
Contact: Jake Krong 801-507-9333 Jake.Krong@imail.org
Virginia
INOVA Fairfax Hospital
Fairfax, Virginia, United States, 22031
Contact: James Piper, MD 703-531-2246 jamesb.piper@inova.org
Contact: Mallory Frazier 202-841-0498 mallory.frazier@inova.org
Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792
Contact: Dixon B Kaufman, MD 312-908-2000 kaufman@surgery.wisc.edu
Contact: Kaelin Grant 6082621551 grantk@surgery.wisc.edu
CANADA —
Quebec
CIUSSS de l’Est- de-l’Île-de-Montréal Installation Hopital Maisonneuve-Rosemont
Montréal, Quebec, Canada, H1T 2M4
Contact: Suzon Collette 51425223403489 suzoncollette@gmail.com
Contact: Lucie Boutin 5142523400 lboutin.hmr@ssss.gouv.qc.ca