MDR-101-MLK (MERCURY) Study: Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants

Multiple Locations


Currently, patients receiving a transplanted kidney are required to take life-long immunosuppressive medications to prevent rejection of the transplanted kidney. These medications carry substantial side effects. In addition, these medicines often do not completely control damage to the kidney from the recipients’ immune system, ultimately causing the kidney to fail.

This study is looking at a novel cell-based therapy to reprogram the recipients’ immune system to accept a transplanted kidney without the need for long term use of immunosuppression drugs.

The purpose of the current Phase 3 study is to demonstrate the efficacy and safety of MDR-101 for the induction of transplant immune tolerance in a prospective, randomized, multicenter clinical trial. MDR-101 is intended to induce mixed lymphohematopoietic chimerism and donor specific immune tolerance in order to preserve transplant kidney function, avert transplant kidney rejection, and eliminate the cumulative and serious side effects associated with immunosuppressive drugs.

Patients will receive either standard anti-rejection medications or a single dose of MDR-101 via IV infustion post-kidney transplant.

The investigational drug and study-related procedures will be provided at no cost. There may also be compensation available for study-related travel and expenses.


You may be eligible for this study if you:

  • Are between 18 to 70 years of age;
  • Have a living, related kidney donation scheduled or upcoming
  • Are HLA and ABO matched with donor


Exclusion criteria:

  • Currently taking immunosuppressive therapy
  • Donor with a history of type 1 or type 2 diabetes melliltus
  • Other eligibility criteria may apply


Find out if you might be eligible by contacting:

Lenuta Micsa, MD @ 646.239.9748 or

Mercury Medeor @ 646.239.9748 or




Mayo Clinic Arizona
Phoenix, AZ

Contact: Caroline Jadlowiec    480-342-6429



University of California San Diego Moores Cancer Center

La Jolla, California, United States, 92037

Contact: Mita Shah, M.D.    858-657-8043  


Loma Linda University Medical Center

Loma Linda, California, United States, 92354

Contact: Michael De Vera, MD    909-558-3650  

Contact: Diane Scavone    909-558-3670



Los Angeles, California, United States, 90033

Contact: Yasir Qazi, M.D.    323-442-5100  

Contact: Lily Jara    3234426038  


Stanford University Medical Center

Stanford, California, United States, 94305

Contact: Stephan Busque, MD    650-498-6189

Contact: Asha Shori    650-736-0245


University of Colorado

Aurora, Colorado, United States, 80045

Contact: Erik Stites, MD       ERIK.STITES@CUANSCHUTZ.EDU

Contact: Janis Cicerchi    303-724-0183 


Yale University

New Haven, Connecticut, United States, 06519

Contact: Ethan Marin, MD    203-785-6221 

Contact: Ricarda Tomlin    203-785-2073  


District of Columbia

Georgetown University Medical Center

Washington, District of Columbia, United States, 20007

Contact: Takeda Harris    202-444-6395  



Mayo Clinic Hospital     

Jacksonville, Florida, United States, 32224

Contact: Martin Mai    904-953-2000 



Loyola University Medical Center

Maywood, Illinois, United States, 60153-3328

Contact: Sanjeev Akkina    708-216-6389

Contact: Mary Rose Evans



Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States, 02215

Contact: Susan McDermott, RN    617-632-9841 

Contact: Catherine Helzer    617-632-9919


Mayo Clinic

Rochester, Minnesota, United States, 55905

Contact: Mark Stegall, MD    507-266-2812 

Contact: Nong Braaten    507-538-9617 


New Jersey

RWJ Barnabas Health

Orange, New Jersey, United States, 07052

Contact: Anup Patel, MD    973-322-2146 

Contact: Nasreen Ali    973-322-2165 


New York

Upstate University Hospital

Syracuse, New York, United States, 13210

Contact: Mark Laftavi, M.D.    716-898-3394

Contact: Iulia Movileanu    3154644766 



University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States, 44106

Contact: Kenneth Chavin, MD    216-844-5396

Contact: Tricia Young    (216) 844-5396 



Thomas Jefferson University

Philadelphia, Pennsylvania, United States, 19107

Contact: Ashesh Shah, MD    317-496-7944  

Contact: Dee Rinaldi    215-503-1765



Baylor University Medical Center

Dallas, Texas, United States, 75246

Contact: Bernard Fischbach, M.D.    817-922-7667 

Contact: Sharon Primeaux  


The Methodist Hospital

Houston, Texas, United States, 77030

Contact: Ahmed Gaber, MD    713-441-6174

Contact: Darrel Cleere    713-441-6232



Intermountain Transplant Center

Murray, Utah, United States, 84107

Contact: Diane Alonso, MD    801-507-9600 

Contact: Jake Krong    801-507-9333



INOVA Fairfax Hospital

Fairfax, Virginia, United States, 22031

Contact: James Piper, MD    703-531-2246

Contact: Mallory Frazier    202-841-0498  


University of Wisconsin

Madison, Wisconsin, United States, 53792

Contact: Dixon B Kaufman, MD    312-908-2000

Contact: Kaelin Grant    6082621551





CIUSSS de l’Est- de-l’Île-de-Montréal Installation Hopital Maisonneuve-Rosemont

Montréal, Quebec, Canada, H1T 2M4

Contact: Suzon Collette    51425223403489

Contact: Lucie Boutin    5142523400