Noninvasive Evaluation of the Intrarenal Microvasculature in ADPKD

Minnesota, United States

Overview
The investigators’ broad objective is to deploy and evaluate the use of super-resolution ultrasound (SRU) imaging coupled with advanced post-processing techniques to assess the intrarenal microvasculature in patients with early ADPKD and healthy volunteers.

Participants in this study will have a renal ultrasound to determine intrarenal microvascular parameters, and an abdominal MRI to determine the patient’s total kidney volume (TKV), and additional vascular parameters. In addition, participants will have a blood and a urine sample collected to determine biomarkers of endothelial function and injury.

Eligibility Criteria
Inclusion Criteria (Patients with ADPKD):

    • Male and female subjects 18 – 40 years of age, inclusive
    • Previous diagnosis of ADPKD (based on Ravine et al. criteria)
    • Class 1 according to imaging classification
    • Estimated GFR> 70 mL/min/m2 (CKD-Epi equation)
    • Ability to provide written, informed consent

Inclusion Criteria (Healthy Volunteers):

    • Male and female subjects 18 – 40 years of age, inclusive
    • Estimated GFR> 70 mL/min/m2 (CKD-Epi equation)
    • Ability to provide written, informed consent

Locations

Minnesota

  • Mayo Clinic
  • Rochester, MN 55905
  • Contact: Genia S Andrist 507-266-9594 andrist.genia@mayo.edu
  • Principal Investigator: Maria V Irazabal, M.D.;Ph.D. 507-293-6388 irazabalmira.maria@mayo.edu