PErfusioN, OxyGen ConsUmptIon and ENergetics in ADPKD (PENGUIN)

Children's Hospital Colorado

Overview

Investigators understand that ADPKD is also a complex metabolic disorder defined by insulin resistance (IR) and mitochondrial dysfunction which may be related to cyst expansion, kidney function decline and contribute to reduced life expectancy. By examining the interplay between renal O2 consumption and energy utilization in young adults with and without ADPKD, the investigators hope to identify novel therapeutic targets to impede development of cyst expansion in future trials.

The investigators propose to study this question with 20 adults with ADPKD. Comparative data will be provided from healthy adults from an ongoing study with similar study design and methods (CROCODILE Study: Control of Renal Oxygen Consumption, Mitochondrial Dysfunction, and Insulin Resistance). Participants will be asked to complete a one day study visit at Children’s Hospital Colorado and will undergo a dual energy x-ray absorptiometry (DXA) to assess body composition, and a 11C-acetate positron emission tomography (PET/CT) scan to quantify renal O2 consumption.

 

Inclusion criteria:

  • 18 to 40 years of age
  • Diagnosis of ADPKD
  • eGFR over 75 ml/min/1.73m^2
  • Body mass index between 18.5 and 30
  • Weight under 350lbs

Exclusion criteria:

  • Diabetes mellitus
  • Pregnant or breastfeeding
  • Anemia
  • Allergy to shellfish or iodine
  • Other eligibility criteria may apply

 

To learn more, contact:

Allison Hilkin @ allison.hilkin@childrenscolorado.org or 720.777.6148

Petter Bjornstad, MD @ petter.bjornstad@childrenscolorado.org or 720.777.4659