The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)

Multiple Locations

Overview

Currently, patients receiving a transplanted kidney are required to take life-long immunosuppressive medications to prevent rejection of the transplanted kidney. Allograft rejection tests monitor for damage to the kidney from the recipient’s’ immune system, with the goal of catching and addressing this issue before the kidney begins to fail.

This study is an observational registry study to collect data on individuals using traditional allorgraft rejection tests (eGFR) to those using Prospera (a specific diagnostic test). This registry will compare patient management and outcomes in patients who receive Prospera (Prospera arm) to the outcomes of the historical control group (control arm) to determine Prospera’s clinical utility.

There are two arms to this study: A prospective arm and a historical control (retrospective arm). Each participant in the Prospective arm will have received the commercially available Prospera test. Subjects prospectively enrolled and whom consent to “Optional future Research” may have bio-specimens stored for future research. The historical arm (retrospective cohort) will not have any bio-specimens collected or stored.

 

You may be eligible for this study if you:

  • 18 years of age or older
  • Had a kidney transplant within the 60 days of initiating Prospera testing
  • Received a kidney from a genetically different donor (not an identical twin)
  • Were selected by a healthcare provider to receive Prospera dd-cfDNA test according to the regular interval testing schedule as part of their practical care

 

Exclusion criteria:

  • Pregnant
  • Your doctor choses a different allograft rejection test to monitor you post-transplant
  • History of another organ transplant
  • Other eligibility criteria may apply

 

Find out if you might be eligible by contacting:

Contact: Amy Yang, BSN, RN 215-375-4817 proactiveprosperastudy@natera.com

 

Locations:

UNITED STATES —

 

Alabama

 

California

  • University of California Davis Medical Center
  • Davis, CA

 

 

  • Keck School of Medicine USC
  • Los Angeles, CA

 

Connecticut

  • Hartford Hospital
  • Hartford, CT

 

District of Columbia

 

  • George Washington University Hospital
  • Washington, DC

 

Florida

 

  • Florida Health Sciences Center
  • Tampa, FL

 

Illinois

  • Loyola University Medical Center
  • Maywood, IL

 

Kansas

 

Maryland

 

Massachusetts

 

Michigan

  • University of Michigan
  • Ann Arbor, MI

 

  • Henry Ford Health System
  • Detroit, MI

 

  • St. John Hospital and Medical Center
  • Detroit, MI

 

Missouri

  • St. Louis University
  • Saint Louis, MO

 

 

Nevada

  • University Medical Center of Southern Nevada
  • Las Vegas, NV

 

New Jersey

  • Saint Barnabas Medical Center
  • Livingston, NJ

 

New York

  • Erie County Medical Center
  • Buffalo, NY

 

  • Northwell Health
  • Manhasset, NY

 

  • The Research Institute at Westchester Medical Center
  • Valhalla, NY

 

North Carolina

  • East Carolina University
  • Greenville, NC

 

  • Wake Forest University Health Sciences
  • Winston-Salem, NC

 

Ohio

 

  • The University of Toledo
  • Toledo, OH

 

Pennsylvania

  • Lehigh Valley Health Network
  • Allentown, PA

 

Texas

  • UT Southwestern
  • Dallas, TX

 

  • Baylor Scott and White Research Institute
  • Temple, TX

 

Utah

  • University of Utah
  • Salt Lake City, UT

 

Washington

  • University of Washington
  • Seattle, WA